Is Missouri a Nurse Licensure Compact (NLC) state?

Yes — Missouri is a full NLC member. Nurses who hold an active multistate license issued by another compact state may practice in Missouri without applying separately, and Missouri residents may apply for a multistate license through the Missouri Board of Nursing if they meet the NCSBN's Uniform Licensure Requirements. Note that nurses changing their primary state of residence to or from a compact state generally must apply in the new home state within 60 days. Source: NCSBN compact map.

Does the Interstate Medical Licensure Compact (IMLC) work for physicians in Missouri?

Yes — Missouri participates in the IMLC. Eligible physicians can use the compact's expedited pathway to obtain medical licenses in additional member states. Whether Missouri serves as a physician's State of Principal License or only as a license-issuing state varies; check the IMLCC for current specifics. Source: IMLCC.

Does the federal DEA renewal cycle differ in Missouri?

No. DEA practitioner registrations are federal and renew on a three-year cycle regardless of state. Registrations are tied to a specific practice address — not to the holder personally — so multi-site clinicians typically hold one DEA per practice location. Missouri's state-level controlled-substance registration, if it requires one, is separate from the federal DEA.

How does Larch keep Missouri's rules current?

A drift-detection job re-fetches each cited source on a weekly cadence and flags pages where the source content has changed since our last review. Where we don't have a verified detail, we surface "Confirm with [Board]" with a link to the issuing board — never a guess.

Missouri

Clinician license renewal in Missouri

Renewal cycles, fees, CE requirements, and compact membership for nurse practitioners, physician assistants, and physicians in Missouri. Sourced from state boards and the official compact registries; we surface the citation next to every claim and never invent a rule we can’t verify.

Last reviewed 05/08/2026.

Compact membership

Nurse Licensure Compact (NLC)

Full member

Source: nursecompact.com, as of 05/05/2026

Interstate Medical Licensure Compact (IMLC)

Member

Source: imlcc.com, as of 05/05/2026

APRN / nurse practitioner license

Renewal cycle: Biennial. RN licenses expire April 30 of each odd-numbered year. The APRN credential in Missouri is a Document of Recognition without an independent expiration — it follows the RN license cycle.; pr.mo.gov, as of 05/08/2026
Renewal fee: Approximately $85 APRN Document-of-Recognition renewal every two years (the MO Board's renewal page does not fix the dollar figure inline; this approximate is from secondary sources — confirm the current fee with the Board at 573-751-0681 or nursing@pr.mo.gov before relying on it). The underlying RN license renewal is paid separately on the same biennial cycle. Renewal must be completed at least 3 business days before expiration; lapsed licenses require a full reinstatement application plus fingerprint background check.; pr.mo.gov, as of 05/08/2026
Continuing education: Missouri does NOT mandate a statewide CE hour total for APRN renewal. Total CE for advanced-practice maintenance is set by the certifying agency (ANCC, AANP, AACN, AMCB, NBCRNA, PNCB, NCC, etc.); the Board verifies status through national systems (Nursys e-Notify) and direct certifying-agency verification. The APRN Document of Recognition continues so long as the underlying RN license remains current and the certifying-agency status is verified.; pr.mo.gov, as of 05/08/2026
Online renewal available: Confirm with Missouri State Board of Nursing

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Physician assistant license

Renewal cycle: Renewal due by January 31 of the renewal year per 20 CSR 2150-7.120. Cycle is biennial under §334.738 RSMo (verbatim biennial anchor pending a follow-up cycle).; sos.mo.gov, as of 05/08/2026
Renewal fee: $28 PA license renewal fee per 20 CSR 2150-7.200(1)(A) (Missouri Code of State Regulations, Chapter 7 — Licensing of Physician Assistants). A $25 delinquent fee applies on late renewal.; sos.mo.gov, as of 05/08/2026
Continuing education: Missouri delegates PA continuing competence to NCCPA — 20 CSR 2150-7.100(4) requires verification of active NCCPA certification at licensure (and the rule chapter does not set a separate state CE hour count for renewal). NCCPA's 2-year standard is 100 CME credits including at least 50 Category 1 credits, so a Missouri PA practically tracks to that bar via the cert pathway. Same delegation pattern as IN and VA.; sos.mo.gov, as of 05/08/2026
Online renewal available: Confirm with Missouri State Board of Registration for the Healing Arts

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MD / DO license

Renewal cycle: Confirm with Missouri State Board of Registration for the Healing Arts
Renewal fee: Confirm with Missouri State Board of Registration for the Healing Arts
Continuing education: Confirm with Missouri State Board of Registration for the Healing Arts
Online renewal available: Confirm with Missouri State Board of Registration for the Healing Arts

We’re still verifying Missouri State Board of Registration for the Healing Arts’s MD/DO- specific renewal details. The most accurate source is the board itself — visit Missouri State Board of Registration for the Healing Arts.

Track this credential automatically with Larch’s License tracking.

State controlled-substance registration

Some states layer a state-level controlled-substance registration (CSR or CDS) on top of the federal DEA; others rely on the DEA alone. Where Missourirequires one, it carries its own number, fee, and renewal clock — independent of the DEA cycle.

Required in this state: Confirm with Missouri controlled-substances regulator

We’re still verifying Missouri’s state CSR rules. Confirm with the Missouricontrolled-substances regulator (often the Board of Pharmacy or a Department of Health office) before assuming you do or don’t need a state CSR alongside your DEA.

Track DEA + state CSR together with Larch’s DEA + CSR tracker.

Federal DEA registration

DEA registration is federal, not state-issued. DEA practitioner registrations renew on a three-year cycle and are tied to a specific practice address — multi-site clinicians typically hold one DEA per practice location, each with its own number and clock. The first renewal on or after June 27, 2023 also required a one-time MATE Act 8-hour training attestation; once attested, the credit carries forward.

See Larch’s DEA tracking page for details on the federal cycle, multi-site rules, and the MATE Act attestation requirements.

Common questions about Missouri renewals

Is Missouri a Nurse Licensure Compact (NLC) state?: Yes — Missouri is a full NLC member. Nurses who hold an active multistate license issued by another compact state may practice in Missouri without applying separately, and Missouri residents may apply for a multistate license through the Missouri Board of Nursing if they meet the NCSBN's Uniform Licensure Requirements. Note that nurses changing their primary state of residence to or from a compact state generally must apply in the new home state within 60 days. Source: NCSBN compact map.
Does the Interstate Medical Licensure Compact (IMLC) work for physicians in Missouri?: Yes — Missouri participates in the IMLC. Eligible physicians can use the compact's expedited pathway to obtain medical licenses in additional member states. Whether Missouri serves as a physician's State of Principal License or only as a license-issuing state varies; check the IMLCC for current specifics. Source: IMLCC.
Does the federal DEA renewal cycle differ in Missouri?: No. DEA practitioner registrations are federal and renew on a three-year cycle regardless of state. Registrations are tied to a specific practice address — not to the holder personally — so multi-site clinicians typically hold one DEA per practice location. Missouri's state-level controlled-substance registration, if it requires one, is separate from the federal DEA.
How does Larch keep Missouri's rules current?: A drift-detection job re-fetches each cited source on a weekly cadence and flags pages where the source content has changed since our last review. Where we don't have a verified detail, we surface "Confirm with [Board]" with a link to the issuing board — never a guess.

Track every MO credential on one calendar.

Larch keeps a clean clock on every license, DEA, state CSR, board cert, and CE hour. Smart renewal alerts on the schedule you set. Encrypted document vault. License tracker is $5/month or $49/year — bundle with Collaboration + CE for $119/year.

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Sources for Missouri

pr.mo.gov · retrieved 05/08/2026
sos.mo.gov · retrieved 05/08/2026
NCSBN Nurse Licensure Compact Map (PDF) · retrieved 05/05/2026
Interstate Medical Licensure Compact Commission (IMLCC) · retrieved 05/05/2026

Other states

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